Adverse effects of everolimus classified according to the common terminology criteria of adverse events (CTCAE) in a study of 17 TCS patients included mild transient stomatitis (two cases), worsening of infantile acne (one case), increases in serum cholesterol and triglycerides (four cases), and changes in serum phosphate levels (two cases), increase in cholinesterase (two cases), transient neutropenia (two cases), transient anemia (one case), transient lymphopenia (one case) and recurrent infections (seven cases) [16]. This evidence concerns the gene BCHE and Treacher-Collins syndrome.