Patient-related risk factors include sociodemographic characteristics (older age, female sex), comorbidities (smoking, arterial hypertension, diabetes, ischemic heart disease, pre-existing renal insufficiency), existing drug therapies or regimens (diuretics, renin-angiotensin system inhibitors, non-steroidal anti-inflammatory drugs, aminoglycosides, paclitaxel) and biological data (hypoalbuminemia, hypomagnesemia) [3,4,8-10]. The gene discussed is REN; the disease is Hypertension.