Treatment with glycopegylated EHL FVIII in participants with hemophilia A also resulted in a statistically significant improvement in the mean FISH scores, showing a progressive improvement from baseline to 6 (p=0.00018), 12 (p=0.00019), and 24 (p=3.81×106) months, respectively (Figure 2). This evidence concerns the gene F8 and hemophilia A.