SMPA significantly stimulates splenocyte proliferation, promotes the production of anti-inflammatory cytokines such as IL-2, IL-4 and IL-10, inhibits the secretion of pro-inflammatory cytokines such as IL-6 and TNF-α, and enhances NK cells and T lymphocytes cytotoxicity and increased phagocytosis of gastric cancer rat macrophages. This evidence concerns the gene TNF and gastric cancer.