Although the CD147-targeting CAR shows promise for treating solid tumor models (e.g., HCC) and different levels of glycosylation on CD147 between tumors (highly glycosylated on tumors) and healthy tissues (low-level, less-glycosylated CD147 expression in healthy cells), human CD147 (hCD147) is expressed in several tissues, such as the brain and lungs, suggesting potential toxicities.24 Here, BSG is linked to hepatocellular carcinoma.