APRs as serum protein P (Apcs), fibronectin (Fn1), inter-alpha-trypsin inhibitor, heavy chain 4 (Itih4), lipopolysaccharide-binding protein (Lbp), orosomucoid or alpha-1 acid glycoprotein (Orm1 and Orm2), Saa (Saa1, Saa2, Saa3, and Saa4), Crp, prothrombin (F2), Hp, serine protease inhibitor (Serpina1a, Serpina1b, and Serpina 3 n), alpha-2-antiplasmin (Serpinf2), and transferrin receptor protein (Tfrc) were differentially expressed in the serum proteome of mice with ARDS complications due to malaria infection. The gene discussed is F2; the disease is acute respiratory distress syndrome.