APRs as serum protein P (Apcs), fibronectin (Fn1), inter-alpha-trypsin inhibitor, heavy chain 4 (Itih4), lipopolysaccharide-binding protein (Lbp), orosomucoid or alpha-1 acid glycoprotein (Orm1 and Orm2), Saa (Saa1, Saa2, Saa3, and Saa4), Crp, prothrombin (F2), Hp, serine protease inhibitor (Serpina1a, Serpina1b, and Serpina 3 n), alpha-2-antiplasmin (Serpinf2), and transferrin receptor protein (Tfrc) were differentially expressed in the serum proteome of mice with ARDS complications due to malaria infection. Here, SAA2 is linked to acute respiratory distress syndrome.