GNAQ and cystic fibrosis: The mGluR1 and its downstream signaling pathway in PCs involving Gαq (Offermanns et al., 1997), phospholipase C β3 and β4 (PLCβ3, PLCβ4) (Kano et al., 1998; Rai et al., 2021), and protein kinase Cγ (PKCγ) (Kano et al., 1995) are crucial for the late phase of CF elimination.