STAT3 and colorectal carcinoma: We used four stemness inhibitors—salinomycin, SB-431542, JIB-04, and napabucasin—each targeting different pathways (Wnt/β-catenin, TGF-β, histone demethylation, and STAT3, respectively), to evaluate their effects on CMS4 CRC cell lines (HCT116 and SW620) and human peripheral blood-derived macrophages in an indirect co-culture model.