Moreover, when stemness marker CD44 and CD133 expression compared with the capacity to induce macrophage phenotype in transwell co-culture (Figure 1A), we observed a strong correlation between the size of the CD44+/CD133- subpopulation in CRC cell lines and the induction of M2-like macrophage marker CD163 (Supplementary Figure 3I) together with downregulation of M1-like marker CD11c (Supplementary Figure 3J). Here, CD163 is linked to colorectal carcinoma.