In line with these findings, miRNA expression analysis in SLE patients treated with mycophenolate mofetil revealed an upregulation of miR-146a and miR-146b following treatment, accompanied by a significant downregulation of IFNA, IFNB, and STAT1, as well as a trend toward downregulation of NFKB1, all of which are known targets of miR-146a. This evidence concerns the gene STAT1 and systemic lupus erythematosus.