Becauseof this, clinical practice uses both IL-6 and CRP as inflammatory indicators [9].The anti-inflammatory effects of IL-6 in atherosclerosis include inhibition ofthe expression of pro-inflammatory cytokines: IL-1 and TNF-α, as well asincreased expression of the anti-inflammatory cytokine IL-10 and increasedsynthesis of tissue inhibitor of matrix metalloproteinase (TIMP)-1, whichpromotes tissue regeneration [10]. The gene discussed is IL1A; the disease is atherosclerosis.