This suggests that key gene editing in inflammatory cells through bonemarrow transplantation could be a novel intervention strategy for AS.Additionally, in apolipoprotein E (ApoE)-⁣/- mice, the natriuretic peptide receptor C(NPRC), a gene significantly associated with coronary artery disease, isupregulated in AS plaques [18]. The gene discussed is APOE; the disease is coronary artery disorder.