The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor SBC-115076 inhibitscardiac fibroblasts from differentiating into myofibroblasts through theNotch1/hairy and enhancer of split 1 (Hes1) signaling pathway, thereby improving cardiac fibrosis and ventriculardysfunction after myocardial infarction [34]. Here, HES1 is linked to myocardial infarction.