No significantdifferences were found in the SIRT1 and NAMPT expressions in adipose tissues orcirculating levels between CHD patients and controls, possibly due to theproinflammatory state in the control group with aortic valve disease [117].However, the expression levels of SIRT1 and NAMPT among CHD patients differedacross tissue types, with SIRT1 expression in PAT and SAT found to be higher thanin the EAT. The gene discussed is NAMPT; the disease is aortic valve disorder.