SisselÅkra and colleagues [117] further examined the expression of the senescencemarker sirtuin 1 (SIRT1) and nicotinamide phosphoribosyltransferas (NAMPT)enzyme, which regulates SIRT1 activity, in EAT, PAT, and SAT from CHD patients,using individuals with aortic valve disease as controls. The gene discussed is SIRT1; the disease is aortic valve disorder.