PPARGC1A and obesity due to melanocortin 4 receptor deficiency: Transcriptional analysis revealed that EAT displays elevated expression of thebeige adipocyte-specific marker CD137, as well as the thermogenic genesUCP-1, PRDM16, PGC-1α, andPPARγ, and beige adipose tissue (BAT)-specific genes, such as ACTA1,PPARGC1A, troponin C type 1, and troponin I type 1, incomparison with SAT, resulting in a beige/BAT-like appearance [108, 109].However, the thermogenesis ability of EAT may decrease with age, obesity, and CAD[110].