SisselÅkra and colleagues [117] further examined the expression of the senescencemarker sirtuin 1 (SIRT1) and nicotinamide phosphoribosyltransferas (NAMPT)enzyme, which regulates SIRT1 activity, in EAT, PAT, and SAT from CHD patients,using individuals with aortic valve disease as controls. This evidence concerns the gene NAMPT and aortic valve disorder.