Our findings revealed that out of the initial pool of variables, the following were significant predictors in the multivariate analysis: Age, current smoking status, diabetes, history of falls, TDF usage, HIV RNA load (1000-100000 copies/mL), CD4 count, WBC, hemoglobin (Hb), albumin (ALB), vitamin D (VD), and lumbar spine bone mineral density (LS BMD). This evidence concerns the gene GSTM1 and diabetes mellitus.