Activation of Sirt1 in brain microvascular endothelial cells by nicotinamide mononucleotide adenylate transferase 1 (NMNAT1) significantly reduces acetylated p53 in ischemic microvessels, Thereby, the occurrence of apoptosis in microvessels during cerebral ischemia is decreased, leading to a reduction in blood-brain barrier damage following an ischemic stroke (Zhang Y et al., 2022). Here, TP53 is linked to ischemic stroke.