PTGS2 and asthma: Prostaglandin-Endoperoxide Synthase 2 (PTGS2) plays a significant role in asthma and COPD, and its upregulation results in the production of mediators such as prostaglandins and further promotes airway inflammation, increasing symptoms of allergic asthma as well as exacerbations of COPD (Bao et al., 2022; Huang et al., 2024).