In asthma we identified 16 core genes for phthalates, CASP3 was upregulated in two datasets in play epithelial cells, PTGS2 was upregulated only in GSE143303 but had a tendency to be upregulated in GSE67472, and CCND1 was downregulated in play epithelial cells; in combination with the alveolar lavage fluid data we found that TLR4, ESR1, PTGS2, IL10, IL10, TLR4, ESR2, and IL10 were not upregulated in play epithelial cells, and we found that TLR4 was upregulated in play epithelial cells. This evidence concerns the gene ESR2 and asthma.