VGSC subtypes, including Nav1.1, Nav1.2, and Nav1.6, play an essential role in various cognitive disorders such as Alzheimer’s disease, and chronic cerebral hypoperfusion (Hu et al., 2019; Martinez-Losa et al., 2018; Yuan et al., 2022). Here, SCN8A is linked to early-onset autosomal dominant Alzheimer disease.