This crosstalk was later confirmed by Yu et al. [35], demonstrating that PAF-PAFR-dependent increased phosphorylation of EGFR in SKOV3 ovarian cancer cell line was mediated via phospholipase C-β (PLCβ) and intracellular Ca2+ signaling, and dependent on Src tyrosine kinase and metalloproteinases. Here, EGFR is linked to ovarian carcinoma.