The immune cell types implicated in PAF-PAFR mediated systemic immunosuppressive effects include CD4+CD25+FoxP3+ regulatory T cells (Tregs), CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs), and CD163+, CD206+, Arg1+ tumor-associated macrophages (TAMs) [8, 9, 24, 25]. The gene discussed is PTAFR; the disease is neoplasm.