Importantly, as PTEN crosstalks with several oncogenic signaling cascades to regulate the growth/fate of tumor cells, including NSCLC, herein, we discussed the key findings, highlighting the crosstalk of the PTEN and PAFR pathways, and PAFR and EGFR pathways and their significance in cancer and cancer therapies. This evidence concerns the gene PTEN and non-small cell lung carcinoma.