–Personal or family history of premature ASCVD (<60 years)–First-degree relative with elevated levels of Lp(a) (>200 nmol/L)–Familial hypercholesterolemia (FH) or another genetic dyslipidemia–Calcified aortic valve stenosis–10-year medium/limit risk of ASCVD, for risk reclassification. This evidence concerns the gene LPA and metabolic syndrome.