NISCH and non-small cell lung carcinoma: Chao et al. reported an ER-targeting Ir(iii) complex, Ir1 (Fig. 5), that induced ICD via apoptosis in non-small-cell lung cancer (NSCLC).222Ir1 triggered ER stress, which led to the release of Ca2+, mitochondrial dysfunction, and ROS overproduction, culminating in apoptosis via a caspase-dependent pathway.