Another Ir(iii) photosensitizer Ir10 with a phenanthroline ligand modified with a hydrophobic long-chain ER targeting N-phenethylsuccinamide moiety generated ROS upon irradiation in oral squamous cell carcinoma (OSCC), which elicited ER stress, leading to ICD and an upregulation of PD-L1 expression.234 The combination with PD-L1 inhibitor was particularly effective in converting “cold” tumours (with low immune activity) into “hot” tumours (with high immune activity) in vivo. This evidence concerns the gene CD274 and oral cavity squamous cell carcinoma.