CALR and neoplasm: Plecstatin-1 Ru4 is an organoruthenium anticancer drug candidate capable of inducing oxidative stress and exerting ICD in tumour spheroids263 even though it specifically targets a scaffold protein and cytolinker, plectin.264,265 Besides CRT, HSP70 and HSP 90 were also translocated to the cell surface upon Ru4 treatment in vitro.