Another Ir(iii) photosensitizer Ir10 with a phenanthroline ligand modified with a hydrophobic long-chain ER targeting N-phenethylsuccinamide moiety generated ROS upon irradiation in oral squamous cell carcinoma (OSCC), which elicited ER stress, leading to ICD and an upregulation of PD-L1 expression.234 The combination with PD-L1 inhibitor was particularly effective in converting “cold” tumours (with low immune activity) into “hot” tumours (with high immune activity) in vivo. This evidence concerns the gene CD274 and neoplasm.