Subsequently, the co-culture experiment could be repeated in the presence of a CRT-specific antibody or CRT-binding peptide to block the interaction of the phagocytes with the treated tumour cells.99 A statistically significant reduction in phagocyte activation would implicate CRT in the phagocytic response, as expected in ICD induction, and rule out other non-specific causes. The gene discussed is CALR; the disease is neoplasm.