For example, Pt-NHC-containing nanoparticles displayed a superior ability to eradicate triple-negative breast cancer tumour and enhance overall survival in mice.210 When combined with Interleukin-2, Pt-NHC-based nanogel reprogramed the immunosuppressive TME in “immunologically cold” tumours, i.e. markedly reduced TAMs and the infiltration of Tregs, including pancreatic ductal adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC).211. The gene discussed is IL2; the disease is hepatocellular carcinoma.