However, SQSTM1 mRNA levels were increased following Pio administration in both control (2.16-fold; Control + Pio vs. Control + MC, p < 0.001, n = 5) and T2DM groups (1.91-fold; T2DM + Pio vs. T2DM + MC, p < 0.001, n = 5). The gene discussed is SQSTM1; the disease is type 2 diabetes mellitus.