Notably, elevated expression of p53, senescence markers (p16, γ‐H2AX) and SASP markers (PAI‐1 and IL‐6) were significantly elevated in the HF bulge region of 10‐month‐old IGF‐1 Tg mice compared to age‐matched WT littermates (Figures 1g, 2l,m). This evidence concerns the gene IGF1 and hydrops fetalis.