VHL and cancer: Remarkably, this is the very first study reporting the effect of kaempferol on the modulation of different epigenetic mechanisms and the reduction of methylation with the subsequent restoration of different TSGs such as TP53, PTEN (PINK1), RASSF1, WIF1, VHL, RUNX1, RUNX2, RARβ, SOCS1, SOX1, FOXO3, and so forth which are otherwise reported to be inactivated through hypermethylation in different cancers [34] (Figures 3a and 5b).