Promoter [1] hypermethylation TSGs can enhance cancer progression by transcriptional repression in various cancers such as p16INK4a involved in cell cycle control, hMLH1 in colorectal carcinoma [2], p53, DAPK, RASSF1, WIF1, RUNX1, RARβ, SOCS1, SOX1, TIMP in various types of cancers including cervical cancer [3, 33, 34]. The gene discussed is SOX1; the disease is colorectal carcinoma.