Probing TIS control;bcl2 lymphomas compared to equally ADR-exposed Suv39h1–;bcl2 samples by GSEA unveiled strong skewing towards various myeloid gene sets, including DC and Mφ profiles, a facet shared with other TIS, OIS, PICS and VIS models (Supplementary Fig. 1b–d). Here, BCL2 is linked to lymphoma.