Importantly, the Mφ and DC bias was reproduced in CD19+ bead-selected, i.e. B-cell-purified cells from curable Eμ-myc lymphomas (Fig. 5c, d), and further detected in comparison to normal reactive germinal center B (GCB)-cells (Supplementary Fig. 7a), thereby confirming that the observed myeloid skewing was truly attributable to the neoplastic B-cell population and not its tumor microenvironment (TME). Here, CD19 is linked to lymphoma.