Although there was no considerable impact on myeloid marker expression upon Jun knockdown, we found the dominant-negative c-Jun moiety cJunΔN, which is able to disrupt activity of all JUN containing AP-1 dimers66, to reduce expression of the three TF, and also of myeloid lineage transcripts in TIS lymphomas (Supplementary Fig. 4b, h). The gene discussed is JUN; the disease is lymphoma.