We then analyzed expression of monocytic surface markers by flow cytometry and detected a TIS-associated gain of CD11b (integrin alpha M [ITGAM]) or CD115 ([macrophage-]colony stimulating factor [CSF] receptor[-1]), abbreviated as M-CSFR or CSF1R) surface markers on lymphoma subpopulations in response to ADR, γ-irradiation (IRR) or the CDK4/6 inhibitor palbociclib (palbo; Fig. 1f, Supplementary Fig. 2b, c). The gene discussed is ITGAM; the disease is lymphoma.