Remarkably, we noted a shift of the neoplastic B-cells towards monocytoid morphology (with the ANA-1 Mφ cell line as a reference) exclusively in ADR-exposed senescence-capable lymphomas (Fig. 1e), and detected intermediate expression levels of myeloid TF compared to ANA-1 cells and non-senescent lymphomas (Supplementary Fig. 2a). The gene discussed is TF; the disease is lymphoma.