ESR1 and lymphoma: Next, we obtained single-cell RNA sequencing (scRNA-seq) profiles from lymphoma cells in which 4-OH-tamoxifen (4-OHT) conditionally restored senescence capacity by activating a Suv39h1-estrogen receptor fusion in a Suv39h1-deficient background16, and found a strongly TIS-associated expression of DC, PU.1 and other myeloid-related transcriptomic signatures on the scRNA level (Fig. 1d; see related bulk RNA profiles in Suv39h1-proficient vs. -deficient settings in Supplementary Fig. 1d).