In line with the functional role of the three master TF in B-cell lymphoma TIS, enforced expression of ERT2-fused TF in senescence-competent DLBCL cell lines Karpas-422 and RC-K8 (Supplementary Fig. 6a) slowed proliferation, enhanced the senescence response (Fig. 4e, Supplementary Fig. 6b), and induced CD11c expression most strongly when 4-OHT was co-administered with ADR (Fig. 4f, Supplementary Fig. 6c). The gene discussed is ITGAX; the disease is B-cell non-Hodgkin lymphoma.