We utilized primary Eμ-myc transgenic mouse B-cell lymphomas with and without genomic ablation of the senescence-essential H3K9 methyltransferase Suv39h1 and further engineered to overexpress Bcl2 as a well-established model for therapy-induced senescence (TIS)16,25,36–39,46 (Supplementary Fig. 1a). The gene discussed is SUV39H1; the disease is B-cell non-Hodgkin lymphoma.