Out of the Bcs/TMEcs-integrative classification of nine DLBCL lymphoma ecotypes (LE) ordered in association with patient overall survival from shortest (LE1) to longest (LE9)76, DC and PU.1 gene signatures scored highest in LE 4, 7 and 9 (Fig. 6a, Supplementary Fig. 8c). The gene discussed is SPI1; the disease is diffuse large B-cell lymphoma.