Other factors such as Yes-associated protein 1 (YAP1)/Transcriptional activator with PDZ domain (TAZ) or hypoxia-inducible factor 1α (HIF1α), reported to affect type H vessel formation (Sivaraj et al. 2020), may also be potential targets for preventing and treating osteoporosis. The gene discussed is YAP1; the disease is osteoporosis.