As expected, the injection of LFn-flagellin/PA, but not the flagellin 3A mutant, into WT mice also induced coagulopathy or DIC and lethality, as evidenced from prolonged plasma clotting time and increased plasma levels of thrombin-antithrombin III (TAT) complexes (Figures 2A–2C). This evidence concerns the gene SERPINC1 and blood coagulation disease.