IRF3 and nasopharyngeal carcinoma: For instance, circBART2.2 was found to promote PD-L1 transcription through binding retinoic acid-inducible gene I (RIG-I), activating transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor-kappa B (NF-κB), eventually inducing immune escape of nasopharyngeal carcinoma [7].