NT5E and neoplasm: Tumor samples from patients in the chemotherapy and CRT cohorts showed higher CD73 expression in the stroma (median CD73-positive area: 9.3% and 8.1% vs 4.1%; p < 0.0001 and p < 0.01, respectively) (Fig. 2B) and tumor epithelium (1.5% and 3.2% vs 0.6%; p < 0.05 and p < 0.01, respectively) (Fig. 2A), and CD73 expression was also higher in the immune infiltrate for the chemotherapy versus treatment-naïve cohort (median 8.0% vs 3.2%, p < 0.0001) (Fig. 2C).