Finally, in contrast with the MT-ND6 mutations characterized in cancer until now27,30,38,39, we did not observe any relationship between Complex I alterations and metastasis, suggesting that ND6 could be part of the oncojanus genes, a category of genes that differently impact tumor progression depending on both their mutation load and type, making ND6 an interesting gene for future therapeutic investigations40. This evidence concerns the gene MT-ND6 and cancer.