MT-ND6 and neoplasm: Finally, in contrast with the MT-ND6 mutations characterized in cancer until now27,30,38,39, we did not observe any relationship between Complex I alterations and metastasis, suggesting that ND6 could be part of the oncojanus genes, a category of genes that differently impact tumor progression depending on both their mutation load and type, making ND6 an interesting gene for future therapeutic investigations40.