This is clearly established for TDP-43, which is depleted from cell nuclei and accumulates into pathological inclusions in the vast majority of ALS cases [5, 38], as well as for ALS-linked FUS mutations, that cause incorrect nuclear-cytoplasmic localization and condensation of FUS into cytoplasmic SGs [39, 40]. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.