Recent data pointed out an important role of hnRNP A2/B1 in regulating SG dynamics [32], which is known to be affected in ALS-related conditions [46–51], and showed that modifying hnRNP A2/B1 expression affect the dynamics of pathological SGs induced by mutant FUS, thus supporting the hypothesis that A2b/B1b isoforms might impact on this function. Here, FUS is linked to amyotrophic lateral sclerosis.