In support of this notion, elevated protein levels of Smyd3, H3K4me3, and Shcbp1 (Fig. 6f), and p-Mek, and p-Erk and Kras (Fig. 6g) were detected in tumor tissues with OE-Smyd3, but these protein levels were significantly decreased in tumor tissues expressing sgSmyd3 or OE-Smyd3/sgShcbp1. Here, MAPK1 is linked to neoplasm.