Further analysis of different types of breast cancer (Supplementary Fig. 3n, o) showed that approximately 30% of invasive lobular carcinomas exhibited SMYD3 amplification (Supplementary Fig. 3p), and high expression of SMYD3 was also observed in invasive lobular carcinoma and invasive ductal carcinoma in the Curtis and TCGA breast cancer database (Supplementary Fig. 3q, r). Here, SMYD3 is linked to breast carcinoma.