SMYD3 and neoplasm: We first performed functional analysis of HP cells overexpressing (OE) of Smyd3, sgSmyd3, or OE-Smyd3/sgShcbp1 (Fig. 6b) in tumor formation and data revealed that tumor growth was markedly increased by the implantation of HP-OE-Smyd3 cells compared to the HP parental cells, whereas the tumor growth was dramatically decreased in the tumors expressing sgSmyd3 or OE-Smyd3/sgShcbp1 with reduced splenomegaly (Fig. 6c–e and Supplementary Fig. 7a, b).