SMYD3 and neoplasm: The data revealed that disruption of either SMYD3 or SHCBP1 in MDA-MB-231 cells did not affect cell growth in vitro (Fig. 5k) but significantly inhibited tumor growth in both 231 and HCC1937 mice models (Fig. 5l, m and Supplementary Fig. 6k, l) with reversed the splenomegaly phenotype (Fig. 5n and Supplementary Fig. 6j).