T-cell proliferation was recovered when T cells were cocultured with MDSCs from tumors expressing either sgSmyd3 or OE-Smyd3/sgShcbp1 (Fig. 6k, l), demonstrating the strong inhibition of T cell proliferation by MDSCs in tumor tissues with elevated Smyd3-Shcbp1 oncogenic signaling. The gene discussed is SHCBP1; the disease is neoplasm.