The positive correlation was also observed between the expression of Smyd3 and Shcbp1 in premalignant virgin MG, P12 mammary and tumor tissues at both protein and mRNA levels (Fig. 2c, f, g, Fig. 4e and Supplementary Fig. 5a), indicating Shcbp1 might mediate Smyd3 signaling. Here, SHCBP1 is linked to neoplasm.