To explore whether Smyd3 could play a role in breast cancer development in general, we analyzed SMYD3 expression in breast cancers from cBioportal datasets, and the data showed that approximately 24% of breast cancer samples had amplification of Smyd3 gene (Supplementary Fig. 3j, k) and correlated with high expression of SMYD3 (Supplementary Fig. 3l, m). The gene discussed is SMYD3; the disease is breast carcinoma.