In a mouse model of c-Myc–induced HCC, ADH4 expression was regulated via the Akt–mTOR pathway, with the inhibition of adenosine triphosphate production and tumor growth, after TSA treatment.155Thus, ADH4 can serve as an independent prognostic marker and a potential therapeutic target in this context. The gene discussed is ADH4; the disease is hepatocellular carcinoma.