Total and class-I ADH activities in cells are significantly elevated in primary and metastatic liver cancers, but activity in serum is elevated only in metastatic liver cancer.146, 147In a proteomics analysis, Gao et al148classified patients with HBV-related HCC into three subgroups and found that ADH1A was associated significantly with differentiation and survival of this subgroup. The gene discussed is AVP; the disease is hepatocellular carcinoma.