ADH4 and hepatocellular carcinoma: Gene enrichment analysis showed that low expression of these ADH genes correlated positively with pro-cancer signaling pathways.149, 150Furthermore, compared with that in healthy liver tissue, the expression of ADH4 mRNA and protein in HCC tissue was found to be significantly reduced and to correlate positively with survival.151, 152Tumor microenvironment (TME) immune cell infiltration and immune checkpoint expression affect the outcomes of immunotherapy for HCC.