ALDH2 and fatty liver disease: Selective small molecule ALDH2 activators have been reported to accelerate acetaldehyde clearance in mice and to alleviate liver steatosis and cell apoptosis.83, 84However, the potential effects of ALDH2 activation on alcohol consumption limit the application of ALDH2 activators in ALD treatment.85Currently, no drug intended specifically for ALD treatment is available, and abstinence from alcohol remains the foundation of this treatment.