The expression and activity of CYP2E1 are decreased in HCC tissue relative to those in adjacent normal liver tissue.133In real-time polymerase chain reaction analyses, Kinoshita and Miyata134and Ho et al135observed weak CYP2E1 mRNA expression in liver tissue from patients with HCC, which may be related closely to tumor invasiveness and poor prognosis. The gene discussed is CYP2E1; the disease is hepatocellular carcinoma.