CAT and Cirrhosis: Alcohol-related cirrhosis accounts for nearly 60% of cirrhosis cases in Europe, North America, and Latin America, and the number of deaths due to ALD has increased in developed countries in the past decade.61, 62, 63The promoter region (c-262, C > T) of the CAT-encoding gene not only affects CAT activity, but is also related closely to the susceptibility to and severity of alcohol dependence.