ABCG8 and cholelithiasis: Variants in ABCG8, such as the missense variant rs11887534, have been linked to cholelithiasis by several studies.88, 89, 90 It has been hypothesised that rs11887534-C increases the efficiency of the cholesterol transport into the bile lumen, which causes cholesterol hypersaturation of the bile and thereby increases the risk of cholesterol gallstones.88