CREB1 and neoplasm: Specifically, numerous studies have demonstrated the role of CREB in promoting tumor cell proliferation (Shankar and Sakamoto, 2004), apoptotic evasion (Mayr and Montminy, 2001), invasion (Kang et al, 2022), and metastasis (Wu et al, 2007), collectively suggesting that CREB augments tumor growth and expansion.