For example, we have recently found that the promotion of BCL-2 transcription by CREB, induced via a YAP-RASAL2 axis, underpins the mechanism of RASAL2-driven chemoresistance in triple-negative breast cancer (TNBC) (Koh et al, 2021; Man et al, 2025). This evidence concerns the gene RASAL2 and triple-negative breast carcinoma.