Additionally, GBP2 was significantly enriched in the plasma EVs of sepsis patients (Fig. 4J), and its expression positively correlated with CRP levels and vascular injury markers, including ANGPT2, Syndecan-1, and sTM in peripheral blood (Fig. 4K–N), suggesting a potential link between GBP2 expression and vascular barrier disruption. The gene discussed is ANGPT2; the disease is Sepsis.