DLGAP3 and Anxiety: This is an important question because it is well-established that there is a significant comorbidity between anxiety and OCD.9 In this context, a recent study of 206 children and adolescents showed that generalized anxiety disorder was a significant predictor of obsessive-compulsive symptoms as well as risk for OCD.10 Early diagnosis of OCD is important because of the possibility of early intervention, which is a focus of considerable interest.11 Thus, phenotypic manifestations in SAPAP3-KO mice under 4 months old are a key unexplored question.