CENPB and systemic sclerosis: Univariate analysis confirms the association between SSc evolution and RP (p < 0.0001), VC changes (p < 0.0001), puffy hands (p < 0.0001), acrocyanosis (p:0.015), anti-ENA positivity (p:0.038), anti-CENP-B (p:0.001), anti-Topoisomerase-I (p < 0.0001).