XLRS is caused by pathogenic variants in RS1, which encodes retinoschisin, an extracellular protein responsible for cellular adhesion between photoreceptors and bipolar cells, that is, therefore, important in maintaining the structural organization of the retina and signal transmission in the visual pathway (Hahn et al., 2022; Molday et al., 2012; Pennesi et al., 2018). This evidence concerns the gene RS1 and X-linked retinoschisis.