CXCL8 and Familial prostate cancer: Increased levels of these molecules can render prostate cancer cells androgen-independent.20 In an in vitro study on androgen-independent prostate cancer cell line PC3 treated with WRE at 10 mcg/mL for 24 hours, it was found that WRE can decrease expression of both IL-8 and COX2, hence potentially decreasing cancer invasiveness.21 Similarly, W. somnifera was shown to inhibit the activation of nuclear factor kappa B, another important proinflammatory molecule in cancer cells.