AKT1 and cancer: Also, AKBA treatment was associated with increased poly-ADP ribose polymerase cleavage and decreased Bcl2 levels in a dose-dependent manner which indicates increased apoptosis of cancer cells.47 In vitro treatment of PC3 cells with ac-LA showed increased apoptosis of these cells associated with inhibition of Akt and mTOR signaling and disturbed mitochondrial membrane potential.48 Ac-LA treatment also decreased vascular-endothelial growth factor (VEGF) production of PC3 cells, which indicates inhibiting angiogenesis in tumors.