MAPT and Alzheimer disease: The diagnostic performance of plasma Aβ42/40 is relatively lower with the area under the receiver operating characteristic (ROC) curve (AUC) of less than 90%,16, 17, 18 while p‐tau (eg, tau phosphorylated at threonine 217 [p‐tau217], p‐tau231, p‐tau181) have been shown to perform better at detecting AD pathology and differentiating AD from other neurodegenerative disorders.13, 19, 20, 21