TGFB1 and autism: Of note, patients with autism have increased inflammatory cytokines IL-21, IL-22, IFN-γ, and IL-4 from T cells [16, 17], decreased antiinflammatory cytokines TGFβ and IL-10, two functional cytokines produced by Tregs [16–18], activated T cells, and/or autoimmunity [19].