APOE and Mental deterioration: The linear regression models showed that plasma p-tau217 concentrations (R2 = 0.33, corrected Akaike information criterion (AICc) = 7,239.1), tau-PET uptake in the medial temporal lobe (tau-PETMTL, R2 = 0.34, AICc = 7,232.8) and tau-PET uptake in the temporal neocortex (tau-PETNEO, R2 = 0.33, AICc = 7,252.6) were all better predictors of longitudinal cognitive decline than basic models that included age, sex, education and cohort with APOE ε4 status (R2 = 0.24, AICc = 7,507.5) or without APOE ε4 status (R2 = 0.23, AICc = 7,524.3) (Fig. 1c and Supplementary Tables 2 and 3).