The expression of SEMA4B in lung adenocarcinoma strongly correlated with tumor stage and clinical progression108 SEMA4B belongs to the family of semaphorins, a group of conserved proteins that signal through plexins and/or neuropilins and mediate various functions in organogenesis, immune regulation, and angiogenesis109,110. The gene discussed is SEMA4B; the disease is lung adenocarcinoma.