To further investigate if hypomethylation of the two mentioned CpGs was associated with elevated PD-L1/PD-L2 mRNA expression specifically in tumor cells, we analyzed 34 TNBC cell lines with matched RNAseq and DNA methylation data, finding that the cell lines with highest PD-L1 or PD-L2 mRNA expression showed hypomethylation of these CpGs (Fig. 5d), consistent with our own data. Here, PDCD1LG2 is linked to neoplasm.