Finally, shore/CGI hypermethylation and downregulated mRNA expression of the FOXA1 gene seem to be unique to Basal-like tumors irrespective of ER, PR and HER2 status through analysis of 645 TCGA breast cancers of all PAM50 subtypes with matched DNA methylation and RNA-sequencing (RNAseq) data, consistent with the pattern observed in SCAN-B TNBC tumors (Fig. 3g). This evidence concerns the gene ESR1 and breast cancer.