The two epitypes also showed distinct expression of basal-related and steroid response-associated genes (including GATA3 and FOXA1) as assessed by reported biological metagenes (i.e., groups of highly connected, co-expressed genes in breast cancer that have been associated to specific biological traits)33, as well as a general difference of the TIME assessed by tumor infiltrating lymphocytes (TILs) (Fig. 3b–d). The gene discussed is GATA3; the disease is breast cancer.