To demonstrate the utility of our model in learning SV generation mechanisms, we analysed 20 single-cell whole-genome sequencing datasets43, where 8 datasets are from 184-hTERT mammary epithelial cell lines, and 12 datasets belong to FBI tumours from patient-derived xenografts (PDXs) of primary cancer patients, which are enriched in CCNE1 amplifications (Methods, Fig. 6a, Supplementary Data 2). The gene discussed is CCNE1; the disease is cancer.