Functionally, circUHRF1 could promote the proliferation, migration, invasion, and EMT of oral squamous cell carcinoma; mechanistically, circUHRF1 can bind with miR-526b-5p and promote the expression of c-Myc, which acts as a transcription factor to initiate the transcription of TGF-β and ESRP1, and ESRP1 could act as a splicing factor and promote the cyclization of circUHRF1, and then circUHRF1/miR-526b-5p/c-Myc/TGF-β1/ESRP1 positive feedback loop could promote the progression of oral squamous cell carcinoma [39]. The gene discussed is TGFB1; the disease is oral cavity squamous cell carcinoma.