Quantitative comparison reveals that Y1197 and T693 on EGFR were observed with highly positive correlation with its glyco-profile, especially the sialo-fucosyl-biantennary glycan (N5H5F1S1 on N413, N6H3F1S1 on N444, N4H5F1S1 on N603) in both TKI-resistant NSCLC cells. This evidence concerns the gene EGFR and non-small cell lung carcinoma.