Wang et al.34conducted a meta-analysis including 11 RCTs involving T2DM patients5, 54, 55, 64, 67, 75, 76, 77, 78, 79, 80(various subtypes, mostly with placebo as the control arm, but also including two trials using DPP-4 inhibitors and one using insulin) and similarly reported an increased DVT risk (62/29,005 vs. 28/25,078; RR 1.92, 95% CI 1.23–3.00). This evidence concerns the gene INS and type 2 diabetes mellitus.