TNF and allergic disease: Clinical studies have shown that the fixed oil of the herb is an effective analgesic and relieves allergic diseases such as bronchial asthma, atopic dermatitis, and allergic rhinitis by repressing inflammatory mediators [93,94].Twenty RCTs have examined the impact of Nigella sativa (N. sativa) supplementation on inflammatory and oxidative stress biomarkers in the adult population, and they found that it could significantly lower levels of CRP (C-Reactive protein), TNF-α, MDA (Malondialdehyde), SOD (superoxide dismutase), GPx (glutathione peroxidase), and TAC (total antioxidant capacity) [95].