SIRT1 and injury: In a similar study, curcumin showed protective effects against acute lung injury (ALI) by upregulating Sirtuin 1 (SIRT1) and inhibiting NOD-like receptor protein 3 (NLRP3) inflammasome activation, thereby reducing inflammation and pyroptosis [71].Systemically administered curcumin produced a dose-dependent inhibition of NF-kB in gingival tissues of periodontitis disease-induced rats.