VEGFA and myocardial infarction: SCG2 is a neuroendocrine secretory protein belonging to the chromogranin/secretogranin family.[41] Cleavage of SCG2 produces the active peptide neurotropin, which induces coronary angiogenesis after myocardial infarction by enhancing VEGF signaling in endothelial cells.[42] Impaired angiogenesis is an important mechanism in the remodeling of the aging heart.[43] Therefore, SCG2 was predicted to be an aging-related gene.