It has previously been reported that myocardial energy metabolism has an important role in maintaining the normal function of the heart, and disturbances of myocardial energy metabolism often lead to HF.[19] In addition, disturbances of monocarboxylic acid, including lactate acid and pyruvate, can also lead to HF.[20–22] Furthermore, aging impairs VEGF-mediated and androgen-dependent regulation of angiogenesis,[23] and angiogenesis has been reported to contribute to CVD.[24,25] Thus, exploring these biological functions could assist in the prediction of age-related cardiac remodeling. This evidence concerns the gene VEGFA and hydrops fetalis.